Holstein cow with clinical signs of Johne's disease
Clinical signs of Johne’s disease include: diarrhea and rapid weight loss in spite of a good appetite. Notice that this cow does not look sick. Cattle with Johne’s disease typically eat well, have no fever, and so not act sick. There appears to be no breed predisposition. Johne's disease is as common in Holstein cattle as in other dairy breeds. The disease is less common, however, in beef breeds of cattle. This is likely due to differences in husbandry practices between dairy and beef cattle.